Enterprise Standard of Xuzhou Jinpai Pharmaceutical Co., Ltd.

• Generic Name: Colistin Sulfate Soluble Powder

• English Name: Colistin Sulfate Soluble Powder

• Chinese Pinyin: Liusuan Nianjunsu Kerongxingfen

Colistin

This product is a white or almost white powder.

• Pharmacodynamics: Colistin is a polypeptide antibiotic and a basic cationic surfactant. It exerts its bactericidal effect by interacting with phospholipids in the bacterial cell membrane, penetrating the membrane, disrupting its structure, and altering membrane permeability, leading to bacterial death. It is highly effective against aerobic Gram-negative bacteria such as Escherichia coli, Haemophilus, Klebsiella, Pasteurella, Pseudomonas aeruginosa, Salmonella, and Shigella. Gram-positive bacteria are generally insensitive. Complete cross-resistance exists with polymyxin B, but no cross-resistance occurs with other antibiotics.

• Pharmacokinetics: Oral administration results in negligible absorption, but non-gastrointestinal routes allow rapid absorption. The drug distributes quickly into the heart, lungs, liver, kidneys, and skeletal muscles but does not easily penetrate the cerebrospinal fluid, pleural cavity, joint cavities, or infected lesions. It is primarily excreted via the kidneys.

1. Concurrent use with neuromuscular blockers (e.g., muscle relaxants, aminoglycosides) may cause muscle weakness or respiratory arrest.

2. Synergistic effects against Pseudomonas aeruginosa when combined with chelating agents (e.g., EDTA) or cationic detergents, often used for topical infections.

A polypeptide antibiotic used primarily to treat intestinal infections caused by Gram-negative bacteria.

Based on this product:

• Drinking water:

  • Pigs: 0.4–2 g per 1 L water.

  • Chickens: 0.2–0.6 g per 1 L water.

• Feed mixing:

  • Pigs: 0.4–0.8 g per 1 kg feed.

No adverse reactions have been observed when used as directed.

1. Do not use in laying hens producing eggs for human consumption.

2. Continuous use should not exceed one week.

Pigs and chickens: 7 days.

100 g:10 g (300 million units).