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• Generic Name: Florfenicol Powder

• English Name: Florfenicol Powder

• Chinese Pinyin: Fubennikao Fen

Florfenicol

This product is a white or almost white powder.

• Pharmacodynamics: Florfenicol is a broad-spectrum bacteriostatic antibiotic of the amphenicol class. It inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. It exhibits strong activity against various Gram-positive and Gram-negative bacteria, including Pasteurella haemolytica, Pasteurella multocida, and Actinobacillus pleuropneumoniae, which are highly susceptible. In vitro, florfenicol's antimicrobial activity is similar to or stronger than thiamphenicol, and it remains effective against some amphenicol-resistant bacteria (e.g., Escherichia coli, Klebsiella pneumoniae) due to acetylation resistance mechanisms.

  Indications: Bacterial diseases in pigs, chickens, and fish caused by susceptible pathogens, such as:

  • Respiratory diseases in cattle/pigs (Pasteurella, Actinobacillus).

  • Typhoid/paratyphoid (Salmonella), fowl cholera, pullorum disease, colibacillosis.

  • Fish bacterial septicemia, enteritis, or red-skin disease (Aeromonas, Vibrio, Staphylococcus aureus).

• Pharmacokinetics: Rapid oral absorption (therapeutic blood levels within ~1 hour; peak concentrations in 1–3 hours). Bioavailability exceeds 80%. Widely distributed, including crossing the blood-brain barrier. Primarily excreted unchanged in urine (>90%), with minor fecal elimination.

1. Antagonism: Macrolides/lincosamides compete for the same ribosomal target (50S subunit)—avoid concurrent use.

2. Unproven interference: May theoretically reduce bactericidal effects of β-lactams/aminoglycosides (no in vivo evidence).

Amphenicol antibiotic for infections caused by Pasteurella and E. coli.

Based on this product:

• Pigs/Chickens: 0.2–0.3 g per 1 kg body weight, twice daily for 3–5 days.

• Fish: 0.1–0.15 g per 1 kg body weight, once daily for 3–5 days.

Immunosuppression at doses above recommendations.

1. Contraindicated: In laying hens (egg production for human consumption).

2. Caution: Breeding chickens (embryotoxic); pregnant/lactating animals.

3. Avoid: During vaccination or in immunocompromised animals.

4. Dosage adjustment: Required for renal impairment.

• Pigs: 20 days

• Chickens: 5 days

• Fish: 375 degree-days

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