Enterprise Standard of Xuzhou Jinpai Pharmaceutical Co., Ltd.

• Generic Name: Neomycin Sulfate Soluble Powder

• English Name: Neomycin Sulfate Soluble Powder

• Chinese Pinyin: Liusuan Xinmeisu Kerongxingfen

Neomycin Sulfate

Off-white to light yellow powder.

• Pharmacodynamics: Aminoglycoside antibiotic with a spectrum similar to kanamycin. Highly effective against Gram-negative bacilli (e.g., E. coli, Proteus, Salmonella, Pasteurella multocida) and Staphylococcus aureus. Resistant to Pseudomonas aeruginosa, most Gram-positive bacteria (except S. aureus), Rickettsia, anaerobes, and fungi.

• Pharmacokinetics: Poor oral absorption (only 3% excreted in urine; mostly eliminated unchanged in feces). Absorption increases with intestinal inflammation/ulcers.

1. Synergy: With macrolides for mastitis; with β-lactams (penicillins/cephalosporins).

2. Reduced Absorption: Digoxin, vitamin A/B1212.

3. Enhanced Toxicity:

   • Alkaline drugs (e.g., NaHCO33) ↑ efficacy but ↑ toxicity (avoid pH >8.4).

   • Diuretics (e.g., furosemide), erythromycin ↑ ototoxicity.

   • Neuromuscular blockers (e.g., succinylcholine) ↑ paralysis risk.

4. Antagonism: Divalent cations (Ca2+2+/Mg2+2+) inhibit activity.

Aminoglycoside for Gram-negative bacterial gastrointestinal infections.

• Poultry: 0.15–0.23 g per 1 L drinking water for 3–5 days.

Most toxic aminoglycoside but rare toxicity when administered orally/topically.

Contraindicated in laying hens (egg production for human consumption).

• Chickens: 5 days

• Turkeys: 14 days

100 g:32.5 g (32.5 million units).