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• Generic Name: Tiamulin Fumarate Soluble Powder

• English Name: Tiamulin Fumarate Soluble Powder

• Chinese Pinyin: Yanhusuosuan Taimiaojunsu Kerongxingfen

Tiamulin Fumarate

White or off-white powder.

• Class: Pleuromutilin antibiotic (bactericidal at high concentrations).

• Mechanism: Binds to 50S ribosomal subunit, inhibiting protein synthesis.

• Spectrum:

  • Highly active: Mycoplasma, Brachyspira hyodysenteriae (swine dysentery).

  • Gram-positive: Staphylococcus, Streptococcus (except Group D).

  • Limited activity: Actinobacillus pleuropneumoniae; weak against most Gram-negative bacteria.

  • Synergy: Combined with chlortetracycline (1:4) for swine bacterial enteritis/pneumonia.

• Pharmacokinetics:

  • Oral bioavailability: ~85% (pigs); peak plasma concentration in 2–4h.

  • High lung tissue concentration; metabolized to >20 compounds (some active).

  • Excretion: Primarily bile (>70%), urine (~30%).

1. Toxic synergy: Avoid polyether ionophores (e.g., monensin, salinomycin)—risk of paralysis/death in poultry.

2. Antagonism: Macrolides/lincosamides compete for 50S subunit binding.

• Poultry: Chronic respiratory disease (Mycoplasma).

• Swine: Mycoplasma pneumonia, Actinobacillus pleuropneumonia, swine dysentery, proliferative enteritis.

• Swine: 0.1–0.13 g per 1 L water for 5 days.

• Poultry: 0.28–0.56 g per 1 L water for 3 days.

• Pigs: Skin erythema (recommended dose); overdose causes salivation/vomiting/CNS depression.

1. Prohibited: Concurrent use with polyether ionophores.

2. Safety: Avoid eye/skin contact during handling.

• Pigs: 7 days

• Chickens: 5 days

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